趙昱凱 博士

WORKING EXPERIENCE

• Research Fellow, pRED Neuroscience and Rare Disease, Roche, Basel, Switzerland (2023-present)

• Senior Research Scientist, AstraZeneca, Cambridge, UK (2021-2023)

• Study Director, Eurofins BioPharma Product Testing, Munich, Germany (2020-2021)

• Postdoctoral Researcher, Walther-Straub-Institut für Pharmakologie und Toxikologie, LMU, Munich,
  Germany (2019-2020)

• Quality Engineer, Department of Quality Assurance, IMPAX Laboratories, Inc., Zhunan, Taiwan (2012–2014)

• Researcher, Department of Clinical Laboratory Science & Medical Biotechnology, National Taiwan
  University (NTU), Taipei, Taiwan (2011–2012)

• Second Lieutenant, Armed Forces Zuoying General Hospital, Kaohsiung, Taiwan (2010–2011)

​PUBLICATIONS

1. Geisslinger F, Müller M, Chao YK, Grimm C, Vollmar AM, Bartel K. “Targeting TPC2 sensitizes acute
   lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function.” Cell Death Dis.2022 Aug 1;13(8)

2. Siow WX, Kabiri Y, Tang R, Chao YK, Plesch E, Eberhagen C, Flenkenthaler F, Fröhlich T, Bracher F,
   Grimm C, Biel M, Zischka H, Vollmar AM, Bartel K. “Lysosomal TRPML1 regulates mitochondrial
   function in hepatocellular carcinoma cells.” J Cell Sci. 2022 Mar 15;135(6)

3. Netcharoensirisuk P, Abrahamian C, Tang R, Chen CC, Rosato AS, Beyers W, Chao YK, Filippini A, Di
   Pietro S, Bartel K, Biel M, Vollmar AM, Umehara K, De-Eknamkul W, Grimm C. “Flavonoids increase
   melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking
   endolysosomal/melanosomal TPC2.” Sci Rep. 2021 Apr 19;11(1)

4. Müller M, Gerndt S, Chao YK, Zisis T, Nguyen ONP, Gerwien A, Urban N, Müller C, Gegenfurtner FA,
   Geisslinger F, Ortler C, Chen CC, Zahler S, Biel M, Schaefer M, Grimm C, Bracher F, Vollmar AM, Bartel
   K. “Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and
   tumor growth.” Cell Chem Biol. 2021 Aug 19;28(8)

5. Böck J, Krogsaeter E, Passon M, Chao YK, Sharma S, Grallert H, Peters A, Grimm C. “Human genome
   diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair
   associated M484L gain-of-function effect.” PLoS Genet. 2021 Jan 19;17(1)

6. Weber J, Rajan S, Schremmer C, Chao YK, Krasteva-Christ G, Kannler M, Yildirim AÖ, Brosien M,
   Schredelseker J, Weissmann N, Grimm C, Gudermann T, Dietrich A. “TRPV4 channels are essential for
   alveolar epithelial barrier function as protection from lung edema.” JCI Insight. 2020 Oct 15;5(20).

7. Chao YK, Chang SY, Grimm C. “Endo-Lysosomal Cation Channels and Infectious Diseases.” Rev Physiol
   Biochem Pharmacol. 2020 Aug 4.

8. Spix B*, Chao YK*, Abrahamian C*, Chen CC, Grimm C. “TRPML Cation Channels in Inflammation
   and Immunity.” Front Immunol. 2020 Feb 28;11:225.

9. Gerndt S*, Chen CC*, Chao YK*, Yuan Y*, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N,
   Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J,
   Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. “Agonist-mediated switching
   of ion selectivity in TPC2 differentially promotes lysosomal function.” Elife. 2020 Mar 16;9:e54712.

10. Villella VR, Venerando A, Cozza G, Esposito S, Ferrari E, Monzani R, Spinella MC, Oikonomou V, Renga
    G, Tosco A, Rossin F, Guido S, Silano M, Garaci E, Chao YK, Grimm C, Luciani A, Romani L, Piacentini
    M, Raia V, Kroemer G, Maiuri L. “A pathogenic role for cystic fibrosis transmembrane conductance
    regulator in celiac disease.” EMBO J. 2019 Jan 15;38(2).

11. Chao YK*, Schludi V*, Chen CC, Butz E, Nguyen ON, Müller M, Krüger J, Kammerbauer C, Ben-Johny
    M, Vollmar AM, Berking C, Biel M, Wahl-Schott C, Grimm C. "TPC2 polymorphisms associated with a
    hair pigmentation phenotype in humans result in gain of channel function by independent
    mechanisms" PNAS. 2017 Oct 10;114(41):E8595-E8602.

12. Chen CC*, Butz ES*, Chao YK, Grishchuk Y, Becker L, Heller S, Slaugenhaupt SA, Biel M, Wahl-Schott
    C, Grimm C."Small Molecules for Early Endosome-Specific Patch Clamping." Cell Chem Biol. 2017 Jul
    20;24(7):907-916.

13. Chen CC*, Cang C*, Fenske S, Butz E, Chao YK, Biel M, Ren D, Wahl-Schott C, Grimm C.
    "Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes." Nat Protoc.
    2017 Aug;12(8):1639-1658.

14. Nguyen ON*, Grimm C*, Schneider LS, Chao YK, Atzberger C, Bartel K, Watermann A, Ulrich M, Mayr
    D, Wahl-Schott C, Biel M, Vollmar AM. "Two-Pore Channel Function Is Crucial for the Migration of
    Invasive Cancer Cells." Cancer Res. 2017 Mar 15;77(6):1427-1438.

15. Beck S, Henß L, Weidner T, Herrmann J, Müller R, Chao YK, Grimm C, Weber C, Sliva K, Schnierle BS.
    "Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound
    library." Antiviral Res. 2016 Aug;132:85-91.

16. Lin PH, Ke YY, Su CT, Shiao HY, Hsieh HP, Chao YK, Lee CN, Kao CL, Chao YS, *Chang SY.
    “Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the AktPathway.”J. Virology. Sep 2011; 85(17):9114-26

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