簡介
經歷
2025-now
Investigator, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan, R.O.C.
2008 – 2024
Associate Investigator, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan, R.O.C.
2003 – 2008
Assistant Investigator, Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan, R.O.C.
2002 – 2003
Assistant Professor, Department of Immunology, Baylor College of Medicine, Houston, Texas
1998 – 2002
Postdoctoral Associate, Department of Immunology, Baylor College of Medicine, Houston, Texas
1993 – 1994
Research Assistant, Institute of Biomedical Science, Academia Sinica, Taiwan
1990 – 1991
Research Assistant, Veterans General Hospital, Taipei, Taiwan, R.O.C.
1988 – 1989
Training student, Institute of Biomedical Science, Academia Sinica, Taiwan, R.O.C.
學術著作
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Chou HC, Cheng CM, Yang CH, Lin TY, Liu YW, Tan TH, Chen YR*. DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction. J. Biomed. Sci.,29: 40, 2022
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Lin TY, Yang CH, Chou HC, Cheng CM, Liu YW, Wang JY, Huang LR, Tsai SF, Huang SF, Chen YR*. EGFR mutation-harboring lung cancer cells produce CLEC11A with endothelial trophic and tumor-promoting activities. Cancers, 14: 1356, 2022
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Chen YR*, Chou HC, Yang CH, Chen HY, Liu YW, Lin TY, Yeh CL, Chao WT, Tsou HH, Chuang HC, Tan TH*. Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene, 36:6509-6517, 2017
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Yang CH, Yeh YJ, Wang JY, Liu YW, Chen YL, Cheng HW, Cheng CM, Chuang YJ, Yuh CH, Chen YR*. NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish. Sci. Reports, 7: 5241, 2017
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Yang CH, Chou HC, Fu YN, Yeh CL, Cheng HW, Chang IC, Liu KJ, Chang GC, Tsai TF, Tsai SF, Liu HP, Wu YC, Chen YT, Huang SF*, Chen YR*. EGFR over-expression in non-small cell lung cancers harboring EGFR mutations is associated with marked down-regulation of CD82. BBA-Mol. Basis Dis., 1852: 1540–1549, 2015
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Wang JY, Yeh CL, Chou HC, Yang CH, Fu YN, Chen YT, Cheng HW, Huang CY, Liu HP, Huang SF, Chen YR*. Vaccinia H1-related phosphatase (VHR) is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer. J Biol. Chem. 286:10177-10184, 2011
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Li JP, Fu YN, Chen YR*, and Tan TH*.JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J. Biol. Chem. 285: 5472-5478, 2010
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Wang JY, Yang CH, Yeh CL, Lin CH, Chen YR*. Neuroendocrine-associated phosphatase (NEAP) causes down-regulation of epidermal growth factor receptor, subsequently induces the suppression of nerve growth factor-induced differentiation in PC12 cells. J. Neurochem. 107: 1544-1555, 2008
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Fu YN, Yeh CL, Cheng HH, Yang CH, Tsai SF, Huang SF, Chen YR*. EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy. Oncogene, 27: 957-965, 2008
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Chen YR, Fu YN, Lin CH, Yang ST, Hu SF, Chen YT, Tsai SF, Huang SF*. Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants. Oncogene, 25: 1205-1215, 2006